Neurological disabilities are recognized disorders of the brain and nervous system. They play a major role because of its magnitude, manifestation and long-term impact of the person and his/her family as a whole. The above said impact becomes manifold especially with reference to adolescents. The authors based on clinical insight and literature review highlight the various psychosocial issues and challenges faced by the adolescents with disabilities at home, family, peers, cultural setting, workplace, and propose remedial measures to address their special need.